What is Dry Granulation & Its Benefits?
Dry granulation is the process of forming particles—i.e., granulates or granules—from dry powder or powder blend without adding liquid to aid in the process. It serves as an established manufacturing process in the …
The Granulation Process in Tablet Manufacturing
The three most common methods are dry granulation, wet granulation and direct compression. Dry Granulation: Dry granulation, often referred to as roller compaction, is a technique where powders are compacted and densified directly into granules without the use of liquid or heat. Wet Granulation: Wet granulation is a widely …
Novel micro-granular sludge process for highly efficient treatment …
The powder carrier facilitated the rapid micro-granulation of sludge within 20 days and the average particle size increased rapidly from 47 μm to 210 μm. Accordingly, the concentration of mixed liquid volatile suspended solids (MLVSS) increased from 1.8 g/L to 4.3 g/L, which enabled the HPB process to maintain a short hydraulic retention time ...
Pharma-Whitepaper and Product brochures
Pharma-Whitepaper and Product brochures. In our pharmaceutical white papers and product brochures you can learn more about our innovative machines, technologically leading processes and their advantages for pharmaceutical production. Further down on this page, we have listed all downloads for you according to their applications.
L.B. Bohle | Dry Granulation – BRC | Pharmaceutical Industry
Dry granulation is frequently the preferred approach for very bulky or moisture-sensitive products. L.B. Bohle's BRC granulators are suitable for continuous production and can …
L.B. Bohle | Grinding & Sieving Machines
Grinding and sieving machines. Internationally, L.B. Bohle's grinding and sieving machines are considered as state-of-the-art precision granular size reduction facilities pursuant to industry standards. The BTM Hammer Mill, the BRS Sieve System and the BRS Rotation Sieve are ideally suitable for application in continuous and batch productions ...
L.B. Bohle | Fluidized Bed System | Pharmaceutical …
Fluidized bed systems have been used in the pharmaceutical industry for many decades. Adding an aqueous or alcoholic granulation medium compresses the mixture of dry powder particles. The fluid contains a …
L.B. Bohle | Machines & Processes
Product innovations and related patents characterize the corporate history of L.B. Bohle. Since its foundation, the aim of the company was to supply its customers with machines and processes that outperform existing …
Bohle | Continuous Manufacturing | Pharmaceutical Industry
L.B. Bohle offers stand-alone systems for the Continuous Manufacture of twin-screw granulation, drying, dry granulation and coating as well as the QbCon ® production plant. The QbCon ® production system allows for Continuous Manufacturing of pharmaceutical solids from powder to the coated tablet via direct compression, dry and wet granulation.
Moisture-activated dry granulation: The 'one-pot' process
The MADG process. MADG is a process in which moisture is used to activate granule formation, without the need to apply heat to dry the granules. During this process, the generation of moist agglomerates is followed by the stepwise addition and blending of common pharmaceutical ingredients that absorb and distribute the moisture, which …
Review A critical review on granulation of pharmaceuticals …
Fluidized bed granulation is a very important part of wet granulation, it is a mild, adjustable and robust process, in this process, many steps (pre-mixing, granulation, drying) can be performed in the same machine, usually without the need of additional grinding process [1, 37]. Milder process conditions result in higher porosity and …
Powder rheology and compaction behavior of novel micro …
The goal is to compare these new dry and hybrid micro-granulates with conventional spray-dried and dry-granulated powders by determining: grain size, …
L.B. Bohle | Fluidized Bed System | Pharmaceutical …
L.B. Bohle's fluid bed granulation portfolio includes R&D systems for small production volumes as well as production scale systems. Granulation with the. Bohle Fluid Bed Granulator. L.B. Bohle uses the Bohle Uni Cone …
Evaluation of different types of mannitol for dry granulation …
3.2. Dry granulation process. The four different types of mannitol were processed by a roller compactor using a pilot scale equipment operating at different compaction force (F RC) by setting the hydraulic pressure of the floating rollpression force was fixed at 15, 30 and 45 kN, aiming at evaluating the behavior of materials at …
Custom Size Reduction and Processing Services
Granulation is a specialized process to reduce the size of large feedstocks, such as bales, slabs and extruder purging into chips or granules. These granules can then be used as-is or sized-reduced further into powders. Micro pellets. Micro pellets are pellets with a size of 400 mµ, made by using a modern underwater pelletizing technique .
Granulation In The Pharmaceutical Industry I L.B. Bohle
Dry Granulation – BRC. L.B. Bohle's BRC 25 and BRC 100, an innovative dry granulator with gap control, meet the rising market demands for continuous processes. The BRC …
Chapter 6 Dry granulation
In dry fluidized-bed granulation spherical granules of which strength is sufficient to handle outside of a fluidized bed can be obtained from fine cohesive powders of organic and inorganic materials. The granule size converges after a few hours of the granulation, with the overall time that is needed much shorter than that of tumbling …
Powder rheology and compaction behavior of novel micro …
A novel micro-granulation process that operates through an innovative and adjustable route (dry or hybrid) – within the Migratech 4.0 technological framework – allows to obtain powders suitable for the production of porcelain stoneware tiles and slabs. The main technological target, constituted by an improvement of powder performances, has ...
DESIGN AND SCALE-UP OF DRY GRANULATION PROCESSES …
This chapter provides an in-depth review of the relevant literature as well as a practical guide to completing the drug product design and commercialization via dry granulation. It presents an overview of the process components, material considerations and testing, and a stepwise look at the equipment, processes, and scale-up techniques.
Powder rheology and compaction behavior of novel micro-granulates …
[6] Nassetti G, Palmonari C. Dry fine grinding and granulation vs wet grinding and spray drying in the preparation of a redware mix for fast ‐ single ‐ fired vitrified tile. Ceramic Engineeri ...
Bohle | Twin-Screw Granulation | Pharmaceutical …
Granulation with the L.B. Bohle. Twin-Screw Granulator. The BCG Twin-Screw Granulator can be used as stand-alone system or it can be fully integrated into the L.B. Bohle's QbCon ® continuous manufacture line.
Bohle | Twin-Screw Granulation | Pharmaceutical Industry
Twin-ScrewGranulation – BCG. Twin-screw granulation has been the established method for continuous moist granulation since the early 2000s. Twin-screw granulation is designed as a fully continuous process and can be used by companies as a starting point for the successful introduction of continuous manufacturing of pharmaceuticals.
Dry Granulators: Operating principles, subclasses, uses, …
Dry granulator sub-classes are primarily distinguished by the densification force application mechanism and they include; 1. Slugging. 2. Roller compaction. 1. Slugging. In slugging, a large tablet (slug) is produced in a heavy-duty tableting press. This mechanism of dry granulation leads to variation in the weight of one slug to another.
Grinding & Dispersing
In its market sector, the "Grinding & Dispersing" Business Unit of the NETZSCH Group has been a market leader for decades – and that goes for everything from laboratory-scale machines to production plants. The …
Engineered Particle Synthesis by Dry Particle Microgranulation
Report. Engineered Particle Synthesis by Dry Particle. Microgranulation. Monodisperse 10-mm engineered particles are important for many applications, including the electrode materials for Li-ion ...
Granulation
GRANULATION. LB designs and manufactures systems for powder granulation used by different industrial sectors. The granulation process helps powder to slide more easily, so it is compatible with operating processes and use of the finished product according to the customer's requirements. Granulation can be performed dry or wet, both in the ...
Keep it dry — looking at the advantages of dry granulation …
A: Roller compaction is a form of dry granulation, through the aggregation and densification of dry powders into a uniform solid mass (ribbon). The ribbon is then broken down into specific granule size via a milling system, which means that the powder particles are made to adhere to each other to form the larger multi-particulate units — …
LB SUPPLIES A NEW GRINDING PLANT WITH MICRO-GRANULATION …
At AL ANWAR, LB new dry grinding line with micro-granulation, has been fully assembled and ready to be commissioned in the following weeks. The client was in need of implementing a new factory able to produce over 22.000 square meters of double-fired tiles in large size. Thanks to the results achieved by LB in the […]
Dry Fine Grinding and Granulation vs Wet Grinding and
Dry Fine Grinding and Granulation vs Wet Grinding and Spray Drying in the Preparation of a Redware Mix for Fast‐Single‐Fired Vitrified Tile March 2008 DOI: 10.1002/9780470314050.ch3
Granulation techniques and technologies: recent progresses
Introduction. Granulation, a technique of particle enlargement by agglomeration, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. 1 During the granulation process, small fine or coarse particles are converted into large agglomerates called …
